IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
Adam J. Fike, Kristen N Bricker, Michael V. Gonzalez, Anju Maharjan, Tien Bui, Keomonyroth Nuon, Scott M. Emrich, Julia L. Weber, Sara A. Luckenbill, Nicholas M. Choi, Renan Sauteraud, Dajiang J. Liu, Nancy J. Olsen, Roberto Caricchio, Mohamed Trebak, , Ziaur S. M. Rahman
This study identifies B cell-intrinsic and -extrinsic mechanisms by which IRF7 promotes spontaneous autoimmune germinal center and plasma cell responses, autoantibody production, and SLE development.
The Journal of Experimental Medicine · May 2, 2025Peer-reviewedImmunology