Pasquale Saggese

The paper characterizes human ectocentromeric sites as evolutionarily constrained and functionally heterogeneous elements along chromosome arms with context-dependent roles in chromatin state and transcription regulation.

This study shows dietary α-Ketoglutarate reduces lung adenocarcinoma in female mice by altering histone marks and TBX5 expression, while increasing tumor growth in males and modulating the immune microenvironment.