Cinzia Benetti

This study shows SMARCA4 mutations in T-ALL lead to chemotherapy resistance by altering chromatin remodeling at AP-1 regulatory regions, reducing stress response genes.

The paper characterizes human ectocentromeric sites as evolutionarily constrained and functionally heterogeneous elements along chromosome arms with context-dependent roles in chromatin state and transcription regulation.

This paper introduces a transcriptome-driven machine learning classifier to predict molecular subtypes in T-cell Acute Lymphoblastic Leukemia and reveals subtype-specific relapse patterns.