Francesco E. Boccalatte

This study shows SMARCA4 mutations in T-ALL lead to chemotherapy resistance by altering chromatin remodeling at AP-1 regulatory regions, reducing stress response genes.

The paper characterizes human ectocentromeric sites as evolutionarily constrained and functionally heterogeneous elements along chromosome arms with context-dependent roles in chromatin state and transcription regulation.

This paper introduces a transcriptome-driven machine learning classifier to predict molecular subtypes in T-cell Acute Lymphoblastic Leukemia and reveals subtype-specific relapse patterns.

The paper identifies GAPDH as a non-canonical RNA-binding protein in AML that stabilizes transcripts and promotes translation, revealing its role in tumor proliferation.

This study introduces C.Origami, a deep learning model that predicts cell type-specific 3D chromatin organization, enabling in silico genetic screening to identify genomic regions affecting chromatin structure.

This study demonstrates that a circular human artificial chromosome can be transmitted through three generations of mice without health or reproductive issues.