Siqi Wu

AlphaCell simulates perturbation-induced cellular dynamics by addressing limitations in current models through three innovations: latent manifold rectification, biological reality reconstruction, and universal state transition.

The paper clarifies that improper negative data sampling strategies can bias TCR-antigen prediction models like PanPep and advocates for consistent comparison methods.

This study introduces TCRBagger, a weakly-supervised framework for peptide-TCR binding prediction to improve neo-epitope identification in tumor immunotherapy.