Author

Siqi Wu

Center for Excellence in Molecular Cell Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexey SilakoviD· 1 shared Amie K. BoaliD· 1 shared Anhui Wang· 1 shared Binju WangiD· 1 shared Bo SuniD· 1 shared Carsten KrebsiD· 1 shared Chenqi XuiD· 1 shared Dinglin ZhangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

Alexey SilakovORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Catch-bond engineering surpasses high-affinity maturation for T cell receptor therapies against solid tumors

Tianqi Huang, Runyu Wang, Dinglin Zhang, Siqi Wu, Yuanhao Wang, Yuanhao Wang, Zhengxu Ren, Sifan Wang, Lan Li, Yan Zhou, Xiaojing Wang, Yanling Bao, Mingyu Fan, Luxue Zhang, Junshuang Liu, , Xiang Zhao

This study shows that catch-bond engineering improves TCR-T cell therapy efficacy against solid tumors without off-target toxicity, surpassing traditional high-affinity maturation strategies.

bioRxiv · Jul 29, 2026 · PreprintImmunology

Metal Coordination Dynamics Governs Selective Epoxidation in Hyoscyamine 6β-Hydroxylase: Integrated Experimental and Computational Insights

J ZHANG, Lian Wu, Siqi Wu, Xiao Liu, Lina Dong, Eliott S. Wenger, Ridao Chen, Carsten Krebs, Alexey Silakov, Amie K. Boal, Joseph Martin Bollinger Jr., Jiahai Zhou, Binju Wang

This paper investigates the catalytic mechanism of hyoscyamine 6β-hydroxylase, revealing that metal coordination dynamics govern selectivity between hydroxylation and epoxidation reactions.

bioRxiv · Jun 3, 2026 · PreprintBiochemistry