Mechthild Lütge

TumorArchetypeR develops a modular framework to derive signature-based tumor subtypes, resolving fibrotic tumor heterogeneity and identifying clinically relevant subtypes with robust classifiers.

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

The paper analyzes pan-genomes of 155 prokaryotic species to assess how environmental and phylogenetic factors influence strain diversity and pan-genome features.