Author

Burkhard Ludewig

Kantonsspital St. GallenORCID 0000-0002-7685-573XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alain LamarreiD· 1 shared Amirhossein Hajialiasgary NajafabadiiD· 1 shared Amirreza Aleyasin· 1 shared Anna Laura CalvaneseiD· 1 shared Anne GengiD· 1 shared Chris J. WestoniD· 1 shared Christian W. SiebeliD· 1 shared Christine BernsmeieriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperImmunology

Alain LamarreORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Notch signaling pathway is a master regulator of CD8+ T cell exhaustion and differentiation during chronic infection

Dave Maurice De Sousa, Salix Boulet, Frédéric Duval, Eric Perkey, Jean‐François Daudelin, Laure Le Corre, Marie‐Ève Lebel, Alain Lamarre, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Ivan Maillard, Nathalie Labrecque

This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.

bioRxiv · Sep 5, 2026 · PreprintImmunology

PMGen: From Peptide-MHC Structure Prediction to Peptide Generation

Amirhossein Hajialiasgary Najafabadi, Amirreza Aleyasin, Jonas Arne Mehl, Salman Soleiman Fallah, Hasmig Aintablian, Burkhard Ludewig, Michele Mishto, Juliane Liepe, Johannes Söding

PMGen improves peptide-MHC structure prediction and enables structure-guided peptide design, achieving high accuracy and enhancing ML model performance.

Bioinformatics · Jun 1, 2026Peer-reviewedBioinformatics

Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges

Anne Geng, Robert G. Brenig, Julien Roux, Mechthild Lütge, Hung‐Wei Cheng, Emilio Flint, Paul O.G. Lussier, Marie‐Anne Meier, Oltin T. Pop, Patrizia Künzler‐Heule, Matthias Sebastian Matter, Julia Alexis Wendon, Mark J.W. McPhail, Savas Deniz Soysal, David Semela, , Christine Bernsmeier

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

Journal of Hepatology · Jan 14, 2025Peer-reviewedImmunology

Sustained innate interferon is an essential inducer of tertiary lymphoid structures

Anna Laura Calvanese, Virginia Cecconi, Severin Stäheli, Daniel Schnepf, Marc Nater, Paulo Pereira, Julia Gschwend, Mathias F Heikenwälder, Christoph Schneider, Burkhard Ludewig, Karīna Siliņa, Maries F. van den Broek

This study identifies sustained type I interferon signaling as essential for the development of functional tertiary lymphoid structures in the lungs during inflammation.

European Journal of Immunology · Jul 9, 2024Peer-reviewedImmunology