Molecular Biologynpj VaccinesPeer-reviewed
Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens
Gregory M. Martin, Rebecca A Russell, Philipp Mundsperger…·Quentin James Sattentau
This study shows that chemical cross-linking with EDC stabilizes HIV-1 Env trimers without significant structural distortion, improving their stability, morphology, antigenicity, and immunogenicity for vaccine development.