Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens
Gregory M. Martin, Rebecca A Russell, Philipp Mundsperger, Scarlett L Harris, Lu Jovanoska, Luiza Farache Trajano, Torben Schiffner, Katalin Fabian, Monica Tolazzi, Gabriella Scarlatti, Leon R. McFarlane, Hannah M. Cheeseman, Yoann Aldon, Edith E. Schermer, Mariëlle J. van Breemen, , Quentin James Sattentau
This study shows that chemical cross-linking with EDC stabilizes HIV-1 Env trimers without significant structural distortion, improving their stability, morphology, antigenicity, and immunogenicity for vaccine development.
npj Vaccines · Jul 13, 2023Peer-reviewedMolecular Biology