Anna I. Wernick

This study identifies lipid dysregulation linked to mitochondrial dysfunction in Parkinson's Disease brain regions through multi-omics analysis of lipids, proteomics, and mitochondrial activity.

The paper shows that sequencing ambiguity between GBA1 and its pseudogene GBAP1 affects transcriptomic analysis, revealing non-lysosomal functions in the brain and widespread annotation inaccuracies.

The paper identifies novel SNCA transcripts in human dopaminergic neurons and demonstrates their impact on antisense oligonucleotide therapy for Parkinson's disease.

This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

The paper tracks α-synuclein conformational changes in neurons and shows mitochondrial involvement in oligomerization and toxicity.