Author

Alexandre Chappard

University of EdinburghORCID 0000-0002-9522-2575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

David J. ClarkeiD· 2 shared Kiani JeacockiD· 2 shared Mathew H. HorrocksiD· 2 shared Sonia GandhiiD· 2 shared Tilo KunathiD· 2 shared Alexey V. BerezhnoviD· 1 shared Andrey Y. AbramoviD· 1 shared Andrey Yurievich VinokuroviD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

David J. ClarkeORCID

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2 papers

Recent·Most cited

Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates

Rebecca S. Saleeb, Craig Leighton, Jieun Lee, Judi O’Shaughnessy, Kiani Jeacock, Alexandre Chappard, Robyn Cumberland, Sarah R. Ball, Margaret Sunde, David J. Clarke, Kristin Piché, Jacob Alec McPhail, Ariel Louwrier, Rachel C. Angers, Sonia Gandhi, , Mathew H. Horrocks

This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.

bioRxiv · Jun 27, 2023 · PreprintNeuroscience

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

Minee L. Choi, Alexandre Chappard, Bhanu Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I. Fedotova, Alexey V. Berezhnov, Suman De, Christopher J. Peddie, Dilan S. Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna I. Wernick, Zeinab Shadman Zanjani, , Sonia Gandhi

The paper tracks α-synuclein conformational changes in neurons and shows mitochondrial involvement in oligomerization and toxicity.

Nature Neuroscience · Aug 30, 2022Peer-reviewedNeuroscience