Cancer BiologybioRxivPreprint
Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma
Endrit Vinca, Anna C. Ehlers, Alina S. Ritter…·Shunya Ohmura
This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.
3 citations