Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma
Alina Ritter, Malenka Zimmermann, Florian H. Geyer, Pablo Táboas, David Obermeier, Martha J. Carreño Gonzalez, Kimberley M. Hanssen, Tobias Faehling, Jana Siebenlist, Annika Jeschke, Laura Romero‐Pérez, Roland Imle, Ana Banito, Enrique de Álava, Wolfgang Hartmann, , Florencia Cidre‐Aranaz
This study identifies CXADR as a driver of Ewing sarcoma metastasis and shows that targeting AKT signaling with Capivasertib enhances chemotherapy efficacy in CXADR-high tumors.
bioRxiv · Aug 7, 2025 · PreprintCancer Biology