Christina Mertens

Liver sinusoidal endothelial cells integrate metabolic and immune signals for MAPK-dependent BMP6 regulation and hepcidin induction

This study shows that liver sinusoidal endothelial cells (LSECs) integrate metabolic and immune signals through the MAPK pathway to regulate BMP6 and induce hepcidin, maintaining iron homeostasis during inflammation and stress.

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.