T. Hastings Wilson

This paper introduces ZEN, a normalization method for genomic data that reduces technical noise while preserving biological signals, improving alignment across different experimental platforms.

The paper defines a 3D chromatin compartment blueprint that programs histone-to-protamine exchange during spermiogenesis using ATAC-seq, CUT&Tag, and Hi-C.

REnformer predicts chromatin accessibility from single-cell ATAC-seq data, outperforming Enformer in accuracy and error rates, and validates its utility with a known thalassemia variant.