Author
University of UtahORCID 0000-0002-3632-3691Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Bing Feng, Kaniz Fatema, David Austin Nix…·Sumati V. Gupta
This paper identifies a chromatin-altered subtype of urothelial carcinoma defined by SWI/SNF alterations, showing it is sensitive to HDAC inhibition and immunotherapy.
Mashiat Rabbani, Zachary Apell, Timothy J. Parnell…·Saher Sue Hammoud
The paper defines a 3D chromatin compartment blueprint that programs histone-to-protamine exchange during spermiogenesis using ATAC-seq, CUT&Tag, and Hi-C.
Emily J. Parnell, Timothy J. Parnell, David J. Stillman
The paper investigates a Tup1 mutant in yeast, finding it acts as a coactivator rather than a corepressor, challenging the classic model of gene repression.
Emily J. Parnell, Timothy J. Parnell, Chao Yun Irene Yan…·David J. Stillman
The paper shows that Ash1 repressor binds to the HO promoter in yeast, requiring nucleosome eviction by Swi5 for access, and that this process is linked to repression and promoter resetting.
Alisha Schlichter, Margaret M. Kasten, Timothy J. Parnell, Bradley Robert Cairns
The paper shows Rsc1 and Rsc2 sub-complexes of the RSC chromatin remodeler differ in their ability to remodel partially-unwrapped nucleosomes, with Rsc1 being more effective and essential under certain conditions.
Laura L. McCullough, Trang H. Pham, Timothy J. Parnell…·Tim Formosa
The paper investigates how FACT activity and H3-K56 acetylation influence chromatin architecture and transcription in yeast, finding they optimize transcription frequency and restore chromatin integrity independently of ongoing transcription.