Saher Sue Hammoud

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologies

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

Asymmetric Histone Inheritance Regulates Olfactory Stem Cell Fates During Regeneration

This study shows that asymmetric histone inheritance in olfactory stem cells during regeneration affects cell fate and tissue repair in mice.

A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound Repair and APC-deletion-induced Colon Tumorigenesis

The paper identifies a rare Tcf4 lineage-negative stem cell population in the colon that contributes to wound repair and colon tumorigenesis when Apc is deleted.

3D chromatin compartment of round spermatids encodes the spatiotemporal program of histone-to-protamine exchange in spermiogenesis

The paper defines a 3D chromatin compartment blueprint that programs histone-to-protamine exchange during spermiogenesis using ATAC-seq, CUT&Tag, and Hi-C.

ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements

This study identifies ZCWPW1 as a chromatin-based regulator of telomere architecture and meiotic chromosome movements, independent of PRDM9.

A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness

This study shows that protamine PTMs create heterogeneous chromatin states in sperm, affecting fertility and chromatin integrity.

Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

Single-oocyte transcriptional profile of early-stage human oocytes reveals differentially expressed genes in the primordial and transitioning stages.

The paper analyzes single-oocyte RNA sequencing data from early-stage human follicles to identify differentially expressed genes between primordial and transitioning stages.

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women

This paper presents a single-cell RNA sequencing atlas of the human uterus, identifying 39 cell subtypes and proposing a consensus annotation system, while highlighting dynamic changes and potential progenitor cells across menstrual cycle phases.

Protamine 2 Deficiency Results In Septin 12 Abnormalities

This study shows that Protamine 2 deficiency leads to Septin 12 abnormalities in sperm, affecting motility and morphology.

Equalizing epigenetically imprinted centromeres in early mammalian embryos

The paper tracks CENP-A dynamics in mouse gametes and embryos, showing sex-specific differences in centromere maintenance and equalization during early development.

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified by scRNA-seq

This study uses scRNA-seq to identify cellular heterogeneity in human fallopian tubes, revealing distinct cell types and changes in disease states.

Placental gene expression-based cell type deconvolution: Cell proportions drive preeclampsia gene expression differences

The paper deconvolves placental gene expression data to show cell type proportions drive preeclampsia gene expression differences, reducing differentially expressed genes after adjustment.

Tcf21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration

This study identifies Tcf21+ mesenchymal progenitors in mouse testis that contribute to somatic cell development, homeostasis, and regeneration.

Micrococcal nuclease sequencing of porcine sperm suggests a nucleosomal involvement on semen quality and early embryo development

The paper uses micrococcal nuclease sequencing on porcine sperm to identify nucleosomal fractions and links them to semen quality and early embryo development.

Regulation of meiotic progression by Sertoli-cell androgen signaling

The paper shows that Sertoli-cell androgen signaling is not required for meiotic prophase initiation but is essential for meiotic division phase competence in spermatocytes.

Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis

The paper uses single-cell RNA sequencing to compare spermatogenesis in human, macaque, and mouse testes, identifying conserved and divergent molecular features across species.