Author

April Ann Apfelbaum

Broad InstituteORCID 0000-0002-3551-4429Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Dana NovikoviD· 2 shared Elizabeth R. LawloriD· 2 shared Emma D. WrenniD· 2 shared Eric S. FischeriD· 2 shared Hyesung JeoniD· 2 shared Ke Xia CaiiD· 2 shared Keith Lloyd LigoniD· 2 shared Michael J. EckiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Dana NovikovORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedJan 21, 2026

Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma

Emma D. Wrenn, Jacob C Harris, April Ann Apfelbaum…·Elizabeth R. Lawlor

The paper identifies TGFβ2 as a driver of a hybrid transcriptional state in Ewing sarcoma cells, promoting metastasis through ECM deposition and invasion.

5 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 18, 2025

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

Sean A. Misek, Anna Borgenvik, Daniel Christen…·Pratiti Bandopadhayay

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

1 citation

humanproteomics

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Cancer BiologyNature CommunicationsPeer-reviewedJul 31, 2025

A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomas

April Ann Apfelbaum, Eric Morin, Dominik Sturm…·Pratiti Bandopadhayay

This study identifies FGFR alterations in pediatric gliomas, their association with specific histologies, and their response to targeted therapies.

20 citationstop 2%

humanwhole-genome sequencing

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Cancer BiologyBrain PathologyPeer-reviewedJun 30, 2025

Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

Shadi Zahedi, Kent A. Riemondy, Tian Liu…·Jean M. Mulcahy Levy

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.

12 citationstop 5%

humanscRNA-seq

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GenomicsbioRxivPreprintJun 18, 2025

Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma.

Olivia G. Waltner, April Ann Apfelbaum, Emma D. Wrenn…·Scott N. Furlan

The paper identifies distinct transcriptional programs in Ewing sarcoma driven by EWS::FLI1 fusions and shows their variability across tumors and cell lines.

DOI 10.1101/2025.06.18.660457

humanscRNA-seq

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