Author

Corette J. Wierenga

Radboud University NijmegenORCID 0000-0001-9073-4099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 6 Organism:mouse· 5 Assay:electronic health records· 4 Assay:imaging· 3 Organism:rat· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Ate BijlsmaiD· 3 shared Carlijn PeerboomiD· 3 shared Lotte J. HersteliD· 3 shared Louk J. M. J. VanderschureniD· 3 shared Casper C. HoogenraadiD· 2 shared Jian Liang· 2 shared René van Dorland· 2 shared T. Wijne· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersNeuroscience

Ate BijlsmaORCID

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10 papers

Recent·Most cited

Distinct modulation of Ih by synaptic potentiation in excitatory and inhibitory neurons

Lotte J. Herstel, Corette J. Wierenga

The paper compares how synaptic potentiation modulates Ih in excitatory and inhibitory hippocampal neurons, finding opposite effects in CA1 pyramidal neurons and sRad interneurons.

eNeuro · Oct 15, 2024Peer-reviewedNeuroscience

Opportunities for risk-taking during play alters cognitive performance and prefrontal inhibitory signalling in rats of both sexes

Ate Bijlsma, Evelien E. Birza, Tara C. Pimentel, Janneke P. M. Maranus, Marieke J. J. M. van Gaans, José G. Lozeman‐van t Klooster, Annemarie M. Baars, E. J. Marijke Achterberg, Heidi M. B. Lesscher, Corette J. Wierenga, Louk J. M. J. Vanderschuren

This study shows that high-risk play during development affects cognitive flexibility, emotional behavior, and prefrontal inhibitory signaling in rats, with sex-specific effects.

European Journal of Neuroscience · Mar 21, 2024Peer-reviewedNeuroscience

Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus

Carlijn Peerboom, Sam de Kater, Nikki Jonker, Marijn P.J.M. Rieter, T. Wijne, Corette J. Wierenga

This study examines the effects of delaying the postnatal GABA shift on synaptic and membrane properties in hippocampal cultures, finding indirect cell-specific changes rather than direct synaptic development impacts.

Journal of Neuroscience · Jul 12, 2023Peer-reviewedNeuroscience

Treatment with furosemide indirectly increases inhibitory transmission in the developing hippocampus

Carlijn Peerboom, T. Wijne, Corette J. Wierenga

The paper shows that furosemide treatment in developing hippocampal neurons shifts GABAergic responses from depolarizing to hyperpolarizing, indirectly increasing inhibitory transmission.

bioRxiv · Jul 11, 2023 · PreprintNeuroscience

Social play behavior shapes the development of prefrontal inhibition in a region-specific manner

Ate Bijlsma, Louk J. M. J. Vanderschuren, Corette J. Wierenga

The paper investigates how social play behavior affects the development of inhibitory and excitatory neurotransmission in different prefrontal cortex regions in rats.

Cerebral Cortex · May 31, 2023Peer-reviewedNeuroscience

Using SuperClomeleon to measure changes in intracellular chloride during development and after early life stress

Lotte J. Herstel, Carlijn Peerboom, Sten Uijtewaal, Dunya Selemangel, Henk Karst, Corette J. Wierenga

This study uses the SuperClomeleon sensor to measure intracellular chloride changes during development and after early life stress in mouse brain slices.

eNeuro · Nov 1, 2022Peer-reviewedNeuroscience

Axonal CB1 receptors mediate inhibitory bouton formation via cAMP increase

Jian Liang, Dennis L.H. Kruijssen, Aniek C. J. Verschuuren, Bas J. B. Voesenek, Feline F. W. Benavides, Maria Sáez González, Marvin Ruiter, Corette J. Wierenga

The paper shows that axonal CB1 receptors mediate inhibitory bouton formation through cAMP elevation, independent of neuronal activity and Gi/o signaling.

Journal of Neuroscience · Aug 19, 2021Peer-reviewedNeuroscience

Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons

Feline W Lindhout, Robbelien Kooistra, Sybren Portegies, Lotte J. Herstel, Riccardo Stucchi, Basten L. Snoek, Maarten A. F. Altelaar, Harold D. MacGillavry, Corette J. Wierenga, Casper C. Hoogenraad

The paper quantitatively maps transcriptome and proteome changes during human iPSC-derived neuron polarization, identifying extensive remodeling of gene and protein expression.

eLife · Sep 17, 2020Peer-reviewedNeuroscience

Social play is critical for the development of prefrontal inhibitory synapses and cognitive flexibility in rats

Ate Bijlsma, Azar Omrani, Marcia Spoelder, Jeroen P. H. Verharen, Lisa Bauer, Cosette Cornelis, Beleke de Zwart, René van Dorland, Louk J. M. J. Vanderschuren, Corette J. Wierenga

This study shows that social play during early life is essential for developing inhibitory synapses in the prefrontal cortex and cognitive flexibility in rats.

bioRxiv · May 1, 2020 · PreprintNeuroscience

Semaphorin4D induces inhibitory synapse formation by rapid stabilization of presynaptic boutons via MET co-activation

Cátia P. Frias, Jian Liang, Tom Bresser, Lisa Scheefhals, Matthijs van Kesteren, René van Dorland, Hai Yin Hu, Anna Bodzęta, Paul M.P. van Bergen en Henegouwen, Casper C. Hoogenraad, Corette J. Wierenga

This study identifies Sema4D's role in stabilizing presynaptic boutons and forming inhibitory synapses through MET activation and actin remodeling.

Journal of Neuroscience · Mar 26, 2019Peer-reviewedNeuroscience