Feline W Lindhout

The paper shows that slower axon growth in humans, driven by reduced calcium influx, leads to longer axon tracts through prolonged growth duration, with calcium dynamics regulating developmental timing.

This study develops protocols for generating mouse brain organoids that mimic in vivo neurodevelopment and function, showing they closely resemble in vivo models across multiple readouts.

The paper quantitatively maps transcriptome and proteome changes during human iPSC-derived neuron polarization, identifying extensive remodeling of gene and protein expression.