Gary J. Brouhard

The paper investigates DCX's role in cytoskeletal networks during neuronal development by analyzing proteomic changes in a disease-associated mutation.

This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.

This study investigates the competition between microtubule expander (paclitaxel) and compactor (DCX) in vitro and in cells, showing that multiple lattice spacings can coexist.

This study compares the conformational flexibility of Drosophila and bovine tubulins and links it to differences in microtubule dynamic instability.

The paper presents a high-resolution structure of the ciliary tip central pair in Tetrahymena thermophila and identifies proteins that stabilize microtubules.

This study shows that microtubule dynamic instability is sensitive to specific viscogens, with glycerol having a distinct effect compared to other viscogens.

The paper develops methods to measure neurite extension and nucleokinesis in iPSC-derived neurons and shows that microtubule-targeting drugs significantly affect these processes.

Kappa, an open-source Fiji plugin, fits user-clicked cubic B-splines to image pixels to measure curvature; on synthetic sine waves, Pearson r ≃ 0.95 at signal-to-noise above 15 dB.