Andrew N. Bayne

GBAviewer maps GBA1 variants onto GCase structures to aid in understanding their structural impact on Parkinson's disease.

This study shows that N-terminal acetylation of α-synuclein reduces aggregation, uptake, seeding, and toxicity in Parkinson's disease models.

This study identifies digenic inheritance of SPG7 and AFG3L2 mutations as a cause of motor neuron and cerebellar disorders in 17 patients.

This study investigates how the human mitochondrial processing peptidase (MPP) recognizes and processes the N-terminal targeting sequence of PINK1, revealing its binding mechanism and functional implications.

This study compares the conformational flexibility of Drosophila and bovine tubulins and links it to differences in microtubule dynamic instability.

MTSviewer integrates tools to visualize mitochondrial targeting sequences, cleavage sites, mutations, and structural data for human and yeast mitochondrial proteomes.

The paper develops a mass spectrometry-based method to measure protein turnover in human induced pluripotent stem cell organoids, comparing results to primary cell cultures and in vivo models.

The paper identifies TRAF6 as an interactor of misfolded SOD1 in ALS, showing it promotes aggregation through ubiquitination.