Author

Muriel Sébastien

McGill UniversityORCID 0000-0002-1652-5368Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam G. HendricksiD· 3 shared Gary J. BrouhardiD· 3 shared Alexandra L. PaquetteiD· 2 shared Brooke A. TurkaljiD· 1 shared Chengqian Zhou· 1 shared Daniel BeaudetiD· 1 shared Emily N. P. ProwseiD· 1 shared Heidi May McBrideiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

Adam G. HendricksORCID

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3 papers

Recent·Most cited

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment

Emily N. P. Prowse, Brooke A. Turkalj, Muriel Sébastien, Lale Gursu, Daniel Beaudet, Jia Feng, Chengqian Zhou, Heidi May McBride, Gary J. Brouhard, Mahmoud A. Pouladi, Adam G. Hendricks

This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.

iScience · Apr 17, 2026Peer-reviewedCell Biology

Competition for microtubule lattice spacing between a microtubule expander and compactor.

Alexandra L. Paquette, Sofía Cruz Tetlalmatzi, Justin A. G. Haineault, Yining Li, Nadja Finkel, Adam G. Hendricks, Gary J. Brouhard, Muriel Sébastien

This study investigates the competition between microtubule expander (paclitaxel) and compactor (DCX) in vitro and in cells, showing that multiple lattice spacings can coexist.

Current Biology · Aug 29, 2025Peer-reviewedCell Biology

Measurements of neurite extension and nucleokinesis in an iPSC-derived model system following microtubule perturbation

Muriel Sébastien, Alexandra L. Paquette, Lilian Ferotin, Adam G. Hendricks, Gary J. Brouhard

The paper develops methods to measure neurite extension and nucleokinesis in iPSC-derived neurons and shows that microtubule-targeting drugs significantly affect these processes.

bioRxiv · Feb 6, 2024Cell Biology