Arko Sen

The paper identifies noncoding regulatory mutations in neuroblastomas that alter gene expression and contribute to tumor development through ASE analysis and integration with genomic data.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

This study identifies how chromatin structure heterogeneity in B-ALL correlates with transcriptional subtypes and developmental stages, revealing its role in disease progression.

The paper identifies a distal enhancer for GATA3 involved in allergic diseases by combining GWAS signals with deletion mapping in T helper 2 cells.

This study evaluates variant callers on ATAC-seq data to discover SNVs and indels, finding VarCA outperforms individual callers in both bulk and single-cell data.

BreakCA identifies indels in regulatory regions using ChIP-seq and ATAC-seq, finding recurrent indels in neuroblastoma cell lines that may be oncogenic.