Author

Sélène T. Tyndale

Salk Institute for Biological StudiesORCID 0000-0001-9805-1049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Arko SeniD· 3 shared Graham McVickeriD· 3 shared Galina A. EriksoniD· 2 shared Yi FuiD· 2 shared Arya R MassaratiD· 1 shared Chae Yun ChoiD· 1 shared Dennis John KuoiD· 1 shared Jean Yasis· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioinformatics

Arko SenORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 4, 2024

Heterogeneity in chromatin structure drives core regulatory pathways in B-cell Acute Lymphoblastic Leukemia

Arko Sen, Zhichao Xu, Sélène T. Tyndale…·Jesse R. Dixon

This study identifies how chromatin structure heterogeneity in B-ALL correlates with transcriptional subtypes and developmental stages, revealing its role in disease progression.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsNucleic Acids ResearchPeer-reviewedJul 8, 2021

Discovering single nucleotide variants and indels from bulk and single-cell ATAC-seq

Arya R Massarat, Arko Sen, Jeff Jaureguy…·Graham McVicker

This study evaluates variant callers on ATAC-seq data to discover SNVs and indels, finding VarCA outperforms individual callers in both bulk and single-cell data.

14 citations

ATAC-seqstatistical model

𝕏 PostBluesky

BioinformaticsbioRxivPreprintApr 11, 2019

BreakCA, a method to discover indels using ChIP-seq and ATAC-seq reads, finds recurrent indels in regulatory regions of neuroblastoma genomes

Arko Sen, Sélène T. Tyndale, Yi Fu…·Graham McVicker

BreakCA identifies indels in regulatory regions using ChIP-seq and ATAC-seq, finding recurrent indels in neuroblastoma cell lines that may be oncogenic.

1 citation

humanChIP-seq

𝕏 PostBluesky