Author

Laura Seaman

University of MichiganORCID 0000-0001-9111-9776Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:Hi-C· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Indika RajapakseiD· 2 shared Sijia LiuiD· 2 shared Alfred Hero· 1 shared Alfred O. HeroiD· 1 shared Cyrus NajarianiD· 1 shared Gerald A. HigginsiD· 1 shared Gerald Higgins· 1 shared Haiming Chen· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Indika RajapakseORCID

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2 papers

Recent·Most cited

Genome Architecture Leads a Bifurcation in Cell Identity

Sijia Liu, Haiming Chen, Scott Ronquist, Laura Seaman, Nicholas Ceglia, Lindsey A. Muir, Walter Meixner, Pin-Yu Chen, Gerald Higgins, Pierre Baldi, Steve Smale, Alfred Hero, Indika Rajapakse

This study shows that MYOD1-mediated reprogramming of human fibroblasts into muscle cells involves a genome architecture bifurcation point preceding transcriptional changes.

bioRxiv · Dec 21, 2017 · PreprintCell Biology

Parental allele-specific genome architecture and transcription during the cell cycle

Haiming Chen, Sijia Liu, Laura Seaman, Cyrus Najarian, Wei-Sheng Wu, Mats E. Ljungman, Gerald A. Higgins, Alfred O. Hero, Max S. Wicha, Indika Rajapakse

The paper investigates parental allele-specific genome architecture and transcription dynamics during the cell cycle in lymphoblastoid cells, identifying allele-biased expression and chromatin organization features.

bioRxiv · Oct 11, 2017 · PreprintGenomics