Max S. Wicha

This paper identifies a TGF-β/S100A9/CXCR2 axis in metastatic TNBC that drives neutrophil expansion and immune suppression, with S100A9 loss enhancing immunotherapy response.

This study investigates how chemical exposures affect biological processes linked to aggressive breast cancer using transcriptomic analysis of normal breast cells from diverse donors.

This study identifies SLC4A11 as a mediator of ammonia import in hepatocellular carcinoma, showing its role in promoting cancer stemness and tumor growth.

The paper maps multi-way chromatin contacts using long reads and identifies cell type-specific transcription clusters by integrating contacts with chromatin accessibility and gene expression.

The paper investigates allele-specific relationships between gene expression and genome structure in human cells using integrated haplotype-resolved data.

The paper uses single-cell RNA sequencing to analyze ALDH+ and CD44+CD24- populations in normal human breast tissue, revealing heterogeneity and hybrid epithelial/mesenchymal cells with stemness and EMT features.

The paper introduces a data-guided algorithm for cellular reprogramming using transcription factors, validated on human fibroblasts and showing potential for tissue regeneration and cancer cell reprogramming.

The paper investigates parental allele-specific genome architecture and transcription dynamics during the cell cycle in lymphoblastoid cells, identifying allele-biased expression and chromatin organization features.