Serge Bonnefoy

This study shows trypanosomatids use homodimeric kinesin-2 motors KIN2A and KIN2B for intraflagellar transport, with KIN2B being essential and KIN2A having a more limited role.

The paper develops a mass spectrometry pipeline to quantify tubulin polyglutamylation in Trypanosoma brucei flagella, identifying novel glutamylation sites and crosstalk with detyrosination.

This study uses tagged tubulin to show that Trypanosoma brucei restricts microtubule assembly to the new flagellum during duplication but allows transient reassembly in mature flagella after cell division.

The paper identifies biallelic LRRC56 mutations causing ciliary dysfunction and laterality defects in two families, linking LRRC56 to intraflagellar transport and dynein arm assembly.