Mariette Matondo

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

This study targets the Sec61 translocon to suppress pathogenic light-chain production in AL amyloidosis, showing that mycolactone and synthetic inhibitors like A317 reduce LC secretion while highlighting the need for client selectivity.

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

This paper shows that the fungal ATRX ortholog SAD-6 uses a unique histone H4 variant for genome surveillance and defense, revealing its role in various genomic regions and a repeat-induced point mutation pathway.

This study shows SARS-CoV-2 ORF9b uses TOMM70 to avoid proteasomal degradation, reduces inflammation, and is not essential for viral replication or lung pathology.

This study identifies USP7 as a regulator of hematopoietic stem cell dormancy by stabilizing HMGA2, showing its role in maintaining stem cell function and longevity.

The paper introduces diagFDR, a framework to improve FDR reporting in proteomics by assessing scope, calibration, and stability, and provides tools for verification.

The paper identifies stress-responsive Mycobacterium tuberculosis subpopulations that influence macrophage polarization and shows targeting GroEL2 can limit inflammation.

The paper identifies a seven-protein complex that stabilizes and facilitates the secretion of the T7SSb effector TelE in SGG.

The paper describes a method to simultaneously extract high-quality RNA and proteins from the same mosquito samples, enabling both RNA-Seq and LC-MS proteomic analyses.

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

This study shows fumarate-based drugs modify gut bacteria via cysteine succination, affecting their functions and interactions in both isolated cultures and microbial communities.

ProteoBench provides a centralized platform for comparing proteomics data analysis workflows, enabling benchmarking and community collaboration.

The paper uses single-cell sequencing to study immune cell development in the choroid plexus, showing B cell maturation and mast cell regulation impact brain development.

This study identifies plasma protein biomarkers for early detection of gastric preneoplasia and cancer using proteomics and validation in a cohort, showing high classification performance.

This study identifies nitrate-induced intracytoplasmic membranes in Mycobacterium tuberculosis that help dampen inflammation during infection.

This study identifies ATG16L1's role in IAV-induced PI4P production at the ER, facilitating vRNP egress by coordinating RAB11A and PI4P-enriched membranes.

The paper develops a mass spectrometry pipeline to quantify tubulin polyglutamylation in Trypanosoma brucei flagella, identifying novel glutamylation sites and crosstalk with detyrosination.

This study tracks genetic and phenotypic changes in Yersinia enterocolitica during a chronic human infection, revealing host-adaptive mutations and antibiotic resistance mechanisms.

MSclassifR is an R package that improves mass spectra classification using machine learning, achieving high accuracy on real datasets and outperforming commercial software.

This study characterizes DNA-carrying extracellular vesicles (EVs) from Methanobrevibacter smithii, revealing their role in DNA and protein export in the gut.

This study uses tagged tubulin to show that Trypanosoma brucei restricts microtubule assembly to the new flagellum during duplication but allows transient reassembly in mature flagella after cell division.

This paper shows that HTLV-1 Rex hijacks CRM1 to retain UPF1 in the nucleus, inhibiting NMD and enabling UPF1 to support viral replication.

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

The paper presents a dual proteomic analysis of Yersinia pestis and human immune cells during blood infection, revealing pathogenic signatures and pathway reshaping.

The paper identifies phosphorylation sites in response to DNA breaks in Trypanosoma brucei and finds a specific RPA-1 phosphorylation event required for resection at a subtelomeric locus.