Liraz Klausner

PEStimate predicts offspring disease risk after polygenic embryo screening by modeling risk reduction and accounting for embryo implantation failure.

This paper models polygenic embryo screening (PES) in IVF patients and finds it leads to small relative risk reductions in most cases due to low live birth rates and limited embryo availability.

The paper evaluates how using polygenic risk scores (PRS) or monogenic testing (PGT-M) for breast cancer risk can lead to errors in embryo selection due to interactions between genetic variants.

This study examines the association between FMR1 premutation and ADHD or anxiety in 53,707 women, finding no significant links but associations with POI and high FSH.