Author

Valerie McDonald

National Institutes of HealthORCID 0000-0001-9164-4378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Avindra NathiD· 2 shared Joseph P. SteineriD· 2 shared Tongguang WangiD· 2 shared Abdel G. ElkahlouniD· 1 shared Anna M. BagnelliD· 1 shared Benjamin D. GastfriendiD· 1 shared Benjamin M. GreenbergiD· 1 shared Bianca Palicha· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Avindra NathORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 23, 2025

A novel frameshift mutation in Phosphoinositide 3-kinase regulatory subunit 1 (PIK3R1) causes immunodeficiency and Amyotrophic Lateral Sclerosis (ALS)

Brice Calco, Colin L. Sweeney, Joseph P. Steiner…·Farinaz Safavi

The paper identifies a novel PIK3R1 frameshift mutation linked to immunodeficiency and ALS, showing haploinsufficiency causes neuronal dysfunction and apoptosis.

DOI 10.1101/2025.05.23.655625

humanscRNA-seq

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NeurosciencebioRxivPreprintMay 20, 2025

3D organoids containing endothelial and neural cells generation by serial inductions of differentiation on human iPSC-derived embryoid bodies

Tongguang Wang, Anna M. Bagnell, Valerie McDonald…·Avindra Nath

This paper develops 3D brain organoids with endothelial and neural cells using sequential differentiation of iPSC-derived embryoid bodies, showing enhanced angiogenesis and SARS-CoV-2 receptor expression.

1 citation

humanscRNA-seq

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