Author

Mikko Lehtovirta

University of HelsinkiORCID 0000-0001-9165-0516Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:Bayesian inference· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:imputation· 1 Approach:mixed model· 1

Frequent Co-Authors

Rashmi B. PrasadiD· 2 shared Abdelrahman G. ElnahasiD· 1 shared Alexander I. YoungiD· 1 shared Alexandros GiannelisiD· 1 shared Andrea GannaiD· 1 shared Andres MetspaluiD· 1 shared Andria Theodoulou· 1 shared Ann-Marie T. Richard· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Rashmi B. PrasadORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintOct 1, 2024

✦ In-depth digest

Family-GWAS reveals effects of environment and mating on genetic associations

Tammy Tan, Hariharan Jayashankar, Junming Guan…·Alexander I. Young

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

47 citations

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsNature GeneticsPeer-reviewedNov 1, 2019

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoît Hastoy…·Leif Groop

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

144 citationstop 1%

humanexperimental assay

𝕏 PostBluesky