PhysiologybioRxivPreprint
Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis
Shijun Deng, Jessica Freed, Grace Y. Lee…·Gökhan S. Hotamışlıgil
This study identifies a cholesterol-responsive interaction between NFE2L1 and INSIG1 that sustains cholesterol balance and prevents MASH by promoting VLDL secretion.
DOI 10.1101/2025.06.09.657856