Author

Jessica Freed

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Angelica D’AmoreiD· 1 shared Benjamin Stefadu· 1 shared Bo Yuan· 1 shared Brendan D. ManningiD· 1 shared Catherine Lourdes SalussoliaiD· 1 shared Emma R. Martin· 1 shared Gizel Askin· 1 shared Gökhan S. HotamışlıgiliD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Angelica D’AmoreORCID

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2 papers

Recent·Most cited

Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis

Shijun Deng, Jessica Freed, Grace Y. Lee, Gizel Askin, Zhe Cao, Özgür Cakici, Bo Yuan, Sheng Tony Hui, Karen Inouye, Isabel Graupera, Gökhan S. Hotamışlıgil

This study identifies a cholesterol-responsive interaction between NFE2L1 and INSIG1 that sustains cholesterol balance and prevents MASH by promoting VLDL secretion.

bioRxiv · Jun 9, 2025 · PreprintPhysiology

AKT-mediated phosphorylation of TSC2 controls stimulus and tissue-specific mTORC1 signaling and organ growth

Yann Cormerais, Samuel C. Lapp, Krystle C. Kalafut, Madi Y. Cissé, Jong Shin, Benjamin Stefadu, Jean Personnaz, Sandra Schrötter, Jessica Freed, Angelica D’Amore, Emma R. Martin, Catherine Lourdes Salussolia, Mustafa Şahin, Suchithra Menon, Vanessa Byles, Brendan D. Manning

This study shows that AKT-mediated phosphorylation of TSC2 regulates tissue-specific mTORC1 signaling and organ growth in mice.

Developmental Cell · Sep 23, 2024Peer-reviewedCell Biology