Gökhan S. Hotamışlıgil

This study shows dietary protein determines insulin's effect on hepatic mTORC1, and mTORC1 isn't elevated in diet-induced obesity despite metabolic impairments.

This study identifies a cholesterol-responsive interaction between NFE2L1 and INSIG1 that sustains cholesterol balance and prevents MASH by promoting VLDL secretion.

The paper develops an organism-level quantitative flux model of energy metabolism in mice by integrating isotope tracing and mass spectrometry, revealing distinct metabolic cycling and oxidation flux patterns for circulating nutrients.

This study identifies FABP4 as a host target that modulates SARS-CoV-2 infection, showing that its inhibition reduces viral replication and lung damage in infected hamsters.

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.