Colin L. Kremitzki

Pathogenic Morphological Signatures of Perturbations in Mitochondrial-Related Genes Revealed by Pooled Imaging Assay

The paper identifies mitochondrial-related genes critical for morphology using a pooled imaging assay and reveals pathogenic variants associated with mitochondrial aggregation.

Classification of iPSC-Derived Cultures Using Convolutional Neural Networks to Identify Single Differentiated Neurons for Isolation or Measurement

The paper presents a CNN-based model for identifying single neurons in iPSC-derived cultures with high accuracy, and demonstrates its applicability to other cell types.

Biophysical Simulation Enables Multi-Scale Segmentation and Atlas Mapping for Top-Down Spatial Omics of the Nervous System

SiDoLa-NS uses synthetic images and multi-scale CNNs to achieve high-precision segmentation of nuclei and tissue structures in nervous system samples.

Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen

The paper introduces Raft-Seq, a functional genomics platform that distinguishes pathogenic MFN2 mutations using high-content imaging, machine learning, and microraft isolation.