Author

Alex L. Yenkin

Broad InstituteORCID 0000-0001-5909-7802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Andrew R. MardersteiniD· 1 shared Ashley L. Blegen· 1 shared Colin L. KremitzkiiD· 1 shared Elizabeth A. KiernaniD· 1 shared Evin M. PadhiiD· 1 shared Hang SuiD· 1 shared Harrison BrandiD· 1 shared J. NguyeniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Andrew R. MardersteinORCID

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2 papers

Recent·Most cited

Multi-omics in the All Of Us Research Program expands mapping genetic mechanisms in health and disease

Evin M. Padhi, Elizabeth A. Kiernan, J. Nguyen, Marianne K. DeGorter, Victoria Silva Rosa, Yulia Mostovoy, Alex L. Yenkin, Hang Su, Lee Lichtenstein, Andrew R. Marderstein, Joshua Gillard, Wail Ba-Alawi, Sophie Parsa, Mine S. Cicek, Jeffrey G. Meyer, , Stephen B. Montgomery

The paper reports on the All of Us multi-omics cohort, identifying 182,246 QTLs and demonstrating rare variant effects across proteomic and transcriptomic data.

medRxiv · Nov 1, 2026 · PreprintGenetic & Genomic Medicine

Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen

Alex L. Yenkin, John C. Bramley, Colin L. Kremitzki, Jason E. Waligorski, Mariel J. Liebeskind, Xinyuan E. Xu, Maria A. Vakaki, Vinay D. Chandrasekaran, Robi David Mitra, Jeffrey Milbrandt, William Buchser

The paper introduces Raft-Seq, a functional genomics platform that distinguishes pathogenic MFN2 mutations using high-content imaging, machine learning, and microraft isolation.

bioRxiv · Mar 12, 2021 · PreprintGenomics