The paper identifies ATOH1 as a pro-metastatic oncogenic driver in SCLC by showing its role in cell survival and metastasis suppression upon depletion.

14 citationstop 5%

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticseLifePeer-reviewedMar 9, 2023

Interrogating the Precancerous Evolution of Pathway Dysfunction in Lung Squamous Cell Carcinoma Using XTABLE

Matthew G. Roberts, Julia Ogden, Arman Hossain…·Carlos Lopez-Garcia

The paper introduces XTABLE, an open-source tool for analyzing PML transcriptomic data, and uses it to study chromosomal instability as a biomarker for LUSC progression and pathway onset.

8 citations

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsEBioMedicinePeer-reviewedDec 17, 2019

A Multistage Sequencing Strategy Pinpoints Many Novel and Candidate Disease Alleles for Orphan Disease Emery-Dreifuss Muscular Dystrophy and Supports Gene Misregulation as its Pathomechanism

Peter Meinke, Alastair R. W. Kerr, Rafal Czapiewski…·Eric C. Schirmer

34 citations

humanwhole-exome sequencing

𝕏 PostBluesky

GenomicsGenome ResearchPeer-reviewedJul 1, 2017

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

Michael I. Robson, Jose I. de las Heras, Rafal Czapiewski…·Eric C. Schirmer

The paper investigates how changes in lamina-associated domains during T-cell activation affect genome organization and gene regulation.

107 citations

humanChIP-seq

𝕏 PostBluesky