Comprehensive characterization of single cell full-length isoforms in human and mouse with long-read sequencing
Luyi Tian, Jafar S. Jabbari, Rachel Thijssen, Quentin A. Gouil, Shanika L. Amarasinghe, Oliver Voogd, Hasaru Kariyawasam, Mei R. M. Du, Jakob Schuster, Changqing Wang, Shian Su, Xueyi Dong, Charity W. Law, Alexis Lucattini, Yair D. J. Prawer, , Matthew E. Ritchie
The paper develops FLT-seq and FLAMES to characterize full-length isoforms in single cells of human and mouse, identifying thousands of unannotated isoforms and linking them to functional modules and drug resistance mutations.
Genome biology · Nov 11, 2021Peer-reviewedGenomics