NeurosciencebioRxivPreprint
Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein
Xiaobo Mao, Hao Gu, Donghoon Kim…·Ted M. Dawson
The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.
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