Enhanced mTORC1 signaling and Protein Synthesis in Parkinson Disease Pathogenesis
Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang, Jaba Mitra, Hu Wang, Saurav Brahmachari, Senthilkumar S. Karuppagounder, Yasuyoshi Kimura, Aanishaa Jhaldiyal, Hyun Hee Kim, Hao Gu, Rong Chen, Javier Redding‐Ochoa, Juan Carlos Troncoso, Taekjip Ha, , Ted M. Dawson
This study identifies that pathological α-synuclein destabilizes the TSC1-TSC2 complex, activates mTORC1, and enhances protein translation, contributing to neurodegeneration in Parkinson's disease.
bioRxiv · Oct 3, 2022 · PreprintNeuroscience