Author

Creg J. Workman

University of PittsburghORCID 0000-0002-9964-9509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Dario A.A. VignaliiD· 4 shared Ted M. DawsoniD· 3 shared Valina Lynn DawsoniD· 3 shared Xiaobo MaoiD· 3 shared Chan CheniD· 2 shared Cyrus Rastegar· 2 shared Deok Jeong· 2 shared Kundlik GadhaveiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Dario A.A. VignaliORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Novel transplantable mouse cell line model recapitulates invasive lobular breast carcinoma (ILC) phenotype and immune microenvironment.

Sayali Onkar, Daisong Liu, Darcie D. Seachrist, Jian Zou, Christopher Merkel, Insa Thale, Alexander Chih-Chieh Chang, Linda R. Klei, Jian Chen, Kristen L. Weber-Bonk, Kai Ding, Laura Savariau, Megan E. Yates, Jagmohan Hooda, Laura P. Stabile, , Steffi Oesterreich

The paper develops a novel mouse cell line model of invasive lobular breast carcinoma that recapitulates human tumor phenotype and immune microenvironment, offering a preclinical platform for therapy evaluation.

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation

Xiuli Yang, Deok Jeong, Graziella Madeo, Ramhari Kumbhar, Ning Wang, Lili Niu, Junkai Hu, Shuya Li, Kundlik Gadhave, Rong Chen, Fatih Akkentli, Creg J. Workman, Dario A.A. Vignali, Mingyao Ying, Antonello Bonci, , Xiaobo Mao

This study shows neuronal LAG3 is essential for α-synuclein propagation and neurodegeneration in Parkinson's disease, suggesting LAG3 as a therapeutic target.

bioRxiv · Jan 3, 2025 · PreprintNeuroscience

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam A. Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, , Xiaobo Mao

This study identifies Lag3 as a neuronal receptor for Tau preformed fibrils, essential for their uptake, propagation, and transmission in Tauopathies.

Advanced Science · Feb 7, 2024Peer-reviewedNeuroscience

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein

Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Longgang Jia, Xiyu Ke, , Ted M. Dawson

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.

bioRxiv · May 1, 2021 · PreprintNeuroscience