Author

Chan Chen

Johns Hopkins UniversityORCID 0000-0001-5823-8247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

Creg J. WorkmaniD· 2 shared Cyrus Rastegar· 2 shared Dario A.A. VignaliiD· 2 shared Shu Zhang· 2 shared Ted M. DawsoniD· 2 shared Valina Lynn DawsoniD· 2 shared Xiaobo MaoiD· 2 shared Yasuyoshi KimuraiD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersNeuroscience

Creg J. WorkmanORCID

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2 papers

Recent·Most cited

NeuroscienceAdvanced SciencePeer-reviewedFeb 7, 2024

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

Chan Chen, Ramhari Kumbhar, Hu Wang…·Xiaobo Mao

This study identifies Lag3 as a neuronal receptor for Tau preformed fibrils, essential for their uptake, propagation, and transmission in Tauopathies.

19 citationstop 5%

mouseprotein structure

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 1, 2021

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein

Xiaobo Mao, Hao Gu, Donghoon Kim…·Ted M. Dawson

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.

15 citations

mouseexperimental assay

𝕏 PostBluesky