Cancer BiologybioRxivPreprint
Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophages.
Xiaoqing Cheng, Khooshbu Kantibhai Patel, Brandon Zhou…·Ron Bose
This paper develops a mouse model of HER2-positive breast cancer cerebellar metastases and identifies IL34-induced Arg1+ macrophages as key drivers of tumor growth, showing that targeting CSF1R can reduce metastases.