Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophages.
Xiaoqing Cheng, Khooshbu Kantibhai Patel, Brandon Zhou, Yiwei Fu, Ryan Cleary, Maureen K. Highkin, Jacob Hsia, Xiaohua Jin, Beth Kohn, Julie L. Prior, Megan S. Michie, Rui Sun, Amanda E.D. Van Swearingen, James D. Quirk, Ian S. Hagemann, , Ron Bose
This paper develops a mouse model of HER2-positive breast cancer cerebellar metastases and identifies IL34-induced Arg1+ macrophages as key drivers of tumor growth, showing that targeting CSF1R can reduce metastases.
bioRxiv · Jun 17, 2025 · PreprintCancer Biology