Lianhua Dong

Complete Telomere-to-Telomere Assembly of the Y Chromosome in the Chinese Quartet

The paper presents a complete, gapless telomere-to-telomere Y chromosome assembly from the Chinese Quartet, improving genomic reference quality for East Asian populations.

A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese Quartet

The paper presents a telomere-to-telomere diploid reference genome for the Chinese Quartet, improving centromere structure annotation and enabling population-specific structural variant analysis.

A ratio-based framework using Quartet reference materials for integrating long- and short-read RNA-seq

This paper develops a ratio-based framework using Quartet reference materials to integrate long- and short-read RNA-seq data, showing hybrid-seq achieves the highest quantification accuracy.

Establishing a Digital PCR-Based Reference Measurement Procedure for Monkeypox Virus: An Inter-laboratory Assessment and Standardization Study

This paper establishes a ddPCR-based reference measurement procedure for MPXV quantification, demonstrating high precision and inter-laboratory consistency.

CCQM-P199: Interlaboratory comparability study of HIV-1 RNA copy number quantification

This study evaluates interlaboratory reproducibility of HIV-1 RNA quantification methods, finding significant variation in results and highlighting the need for improved RNA material characterization.

CCQM-P199b: Interlaboratory comparability study of SARS-CoV-2 RNA copy number quantification

This study evaluates the comparability of SARS-CoV-2 RNA quantification methods across laboratories using RT-dPCR and highlights factors affecting interlaboratory variation.

Haplotype-resolved assemblies and variant benchmark of a Chinese Quartet

This study generates haplotype-resolved assemblies and a variant benchmark for a Chinese monozygotic twin quartet using advanced sequencing and computational methods.

Quartet DNA reference materials and datasets for comprehensively evaluating germline variants calling performance

This paper introduces Quartet DNA reference materials to comprehensively evaluate germline variant calling accuracy across the genome, including difficult regions and batch effects.

Correcting batch effects in large-scale multiomic studies using a reference-material-based ratio method

The paper evaluates seven batch-effect correction algorithms for multiomic data and finds the ratio-based method is more effective, especially when batch effects are confounded with biological factors.

Standardisation of cell-free DNA measurements: An International Study on Comparability of Low Concentration DNA Measurements using cancer variants

This study evaluates the comparability of cell-free DNA measurements using digital PCR across 12 laboratories, showing high technical accuracy for variant copy number and allele frequency.

Ratio-based quantitative multiomics profiling using universal reference materials empowers data integration

This paper introduces ratio-based multiomics profiling using universal reference materials to improve data integration across omics types and batches.

Quartet RNA reference materials and ratio-based reference datasets for reliable transcriptomic profiling

The paper introduces RNA reference materials and ratio-based datasets to improve the reliability and benchmarking of transcriptomic profiling.