Systems BiologybioRxivPreprint
Actionable spatial prostanoid barriers constrain BiTE-driven adoptive T cell immunity in intact human tumors
Bovannak Stewen Chap, Tania Santoro, Paris Kosti…·Denarda Dangaj Laniti
The paper uses patient-derived explants to study BiTE-driven T cell responses in tumors, identifying the COX/PGE2 axis as a barrier to immune activation and showing COX inhibition enhances anti-tumor effects.
DOI 10.64898/2026.03.26.713601