Anthony Wayne Orr

This study shows that SMC-specific deletion of CYGB increases fibrous cap thickness and collagen deposition in atherosclerosis, suggesting CYGB reduces plaque stability.

This study shows EHD1 promotes inflammation and stabilizes sortilin in macrophages, accelerating atherosclerosis through enhanced TNFR2-NF-kB signaling and endocytic recycling.

This study shows fibronectin-binding integrins drive ER stress in endothelial cells under atherogenic conditions, promoting inflammation through JNK-c-Jun signaling.

This study identifies PRC2 as a driver of atherosclerosis by suppressing Klf2/4, and shows that inhibiting PRC2 with tazemetostat reduces plaque progression and improves stability.

This study shows Nck1, but not Nck2, mediates shear stress-induced endothelial permeability through distinct signaling mechanisms.