Author

Arif Yurdagul

Columbia University Irving Medical CenterORCID 0000-0002-7613-6313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Anthony Wayne OrriD· 2 shared Oren RomiD· 2 shared Bishuang CaiiD· 1 shared Brenna H. PearsoniD· 1 shared Brian K. Hubbard· 1 shared Canan Kasikara· 1 shared Cyrine Ben DhaouiD· 1 shared Elizabeth D CockerhamiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersCell Biology

Anthony Wayne OrrORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis

Fanglin Ma, Y Liu, Yang Xu, W Liu, Neha Gupta, Yiwei Zhu, Lieying Xiao, Steven Swee, Irsyad Adam, Erika Zheng, Peipei Ping, James G. Traylor, Oren Rom, Jason Ciril Kovacic, Trevor P. Fidler, , Bishuang Cai

This study shows EHD1 promotes inflammation and stabilizes sortilin in macrophages, accelerating atherosclerosis through enhanced TNFR2-NF-kB signaling and endocytic recycling.

Circulation Research · May 21, 2026Peer-reviewedCell Biology

Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation

Cyrine Ben Dhaou, Zaki Al‐Yafeai, G Ali Cruz-Marquez, Matthew L. Scott, Brenna H. Pearson, Elizabeth D Cockerham, Hanna Li, Jonette M. Peretik, Yuning Hong, Nirav Dhanesha, Arif Yurdagul, Oren Rom, Md. Shenuarin Bhuiyan, Anthony Wayne Orr

This study shows fibronectin-binding integrins drive ER stress in endothelial cells under atherogenic conditions, promoting inflammation through JNK-c-Jun signaling.

bioRxiv · May 31, 2025 · PreprintPathology

Allosteric MAPKAPK2 Inhibitors Improve Plaque Stability in Advanced Atherosclerosis

Lale Özcan, Canan Kasikara, Arif Yurdagul, George Kuriakose, Brian K. Hubbard, Michael H. Serrano‐Wu, Ira A. Tabas

This study shows that MK2 inhibitors TBX-1 and TBX-2 improve glucose metabolism and reduce atherosclerotic plaque instability in mice with established atherosclerosis.

PLoS ONE · May 13, 2021Peer-reviewedMolecular Biology